Keith M. Wilcoxen: search on Z-Library

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1

New methods for the synthesis of fluoroolefins via the palladium catalyzed cross-coupling reaction of 1-fluorovinyl halides with organoboranes and organostannanes

Chen Chen, Keith Wilcoxen, Charles Q Huang, Nathalie Strack, James R McCarthy

Journal:

Journal of Fluorine Chemistry

Year:

2000

Language:

english

File:

PDF, 161 KB

english, 2000

2

Recent Advances of MEK Inhibitors and Their Clinical Progress

John (Yuan), Wang, Keith, Wilcoxen, Kenichi, Nomoto, Sara, Wu

Journal:

Current Topics in Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 389 KB

english, 2007

3

10.1038/35104592

Fernandez-Lopez, Sara, Kim, Hui-Sun, Choi, Ellen C., Delgado, Mercedes, Granja, Juan R., Khasanov, Alisher, Kraehenbuehl, Karin, Long, Georgina, Weinberger, Dana A., Wilcoxen, Keith M., Ghadiri, M. Re

Journal:

Year:

2001

Language:

english

File:

PDF, 81 KB

english, 2001

4

Synthesis and SAR of 8-Arylquinolines as Potent Corticotropin-Releasing Factor1 (CRF1) Receptor Antagonists.

Charles Q. Huang, Keith Wilcoxen, James R. McCarthy, Mustapha Haddach, Thomas R. Webb, Jian Gu, Yun-Feng Xie, Dimitri E. Grigoriadis, Chen Chen

Journal:

Year:

2003

File:

PDF, 100 KB

2003

5

Practical metabolomics in drug discovery

Wilcoxen, Keith M, Uehara, Taisuke, Myint, Khin Than, Sato, Yoshiaki, Oda, Yoshiya

Journal:

Expert Opinion on Drug Discovery

Year:

2010

Language:

english

File:

PDF, 655 KB

english, 2010

6

Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts

Póti, Ádám, Berta, Kinga, Xiao, Yonghong, Pipek, Orsolya, Klus, Gregory T., Ried, Thomas, Csabai, István, Wilcoxen, Keith, Mikule, Keith, Szallasi, Zoltan, Szüts, Dávid

Journal:

British Journal of Cancer

Year:

2018

Language:

english

File:

PDF, 777 KB

english, 2018

7

Discovery of Novel Drugs for Promising Targets

Martell, Robert E., Brooks, David G., Wang, Yan, Wilcoxen, Keith

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 178 KB

english, 2013

8

ChemInform Abstract: Initial Structure—Activity Relationship Studies of a Novel Series of Pyrrolo[1,2-a]pyrimid-7-ones as GnRH Receptor Antagonists.

Yun-Fei Zhu, R. Scott Struthers, Patrick J. Connors Jr., Yinghong Gao, Timothy D. Gross, John Saunders, Keith Wilcoxen, Greg J. Reinhart, Nicholas Ling, Chen Chen

Journal:

Year:

2002

File:

PDF, 34 KB

2002

9

Palladium/Copper (I) halide-cocatalyzed stereospecific coupling of 1-fluorovinylstannanes with aryl iodides and acyl chlorides

Chen Chen, Keith Wilcoxen, Kyung-il Kim, James R. McCarthy

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 221 KB

english, 1997

10

Synthesis and SAR of 8-Arylquinolines as potent corticotropin-Releasing factor1 (CRF1) receptor antagonists

Charles Q. Huang, Keith Wilcoxen, James R. McCarthy, Mustapha Haddach, Thomas R. Webb, Jian Gu, Yun-Feng Xie, Dimitri E. Grigoriadis, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 187 KB

english, 2003

11

Four-Atom-Linked Capped Porphyrins: Synthesis and Characterization

Johnson, Martin R., Seok, Won K., Ma, Wuping, Slebodnick, Carla, Wilcoxen, Keith M., Ibers, James A.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 235 KB

english, 1996

12

Synthesis and initial structure–Activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

Keith M. Wilcoxen, Yun-Fei Zhu, Patrick J. Connors Jr., John Saunders, Timothy D. Gross, Yinghong Gao, Greg J. Reinhart, R.Scott Struthers, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

13

Design and Synthesis of 3-(2-Pyridyl)pyrazolo[1,5-a]pyrimidines as Potent CRF1 Receptor Antagonists.

Charles Q. Huang, Keith M. Wilcoxen, Dimitri E. Grigoriadis, James R. McCarthy, Chen Chen

Journal:

Year:

2004

File:

PDF, 13 KB

2004

14

Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists

Charles Q Huang, Keith M Wilcoxen, Dimitri E Grigoriadis, James R McCarthy, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 277 KB

english, 2004

15

10.1038/35086601

Fernandez-Lopez, Sara, Kim, Hui-Sun, Choi, Ellen C., Delgado, Mercedes, Granja, Juan R., Khasanov, Alisher, Kraehenbuehl, Karin, Long, Georgina, Weinberger, Dana A., Wilcoxen, Keith M., Ghadiri, M. Re

Journal:

Year:

2001

Language:

english

File:

PDF, 248 KB

english, 2001

16

Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5- a ]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Chen,, Wilcoxen, Keith M., Huang, Charles Q., Xie, Yun-Feng, McCarthy, James R., Webb, Thomas R., Zhu, Yun-Fei, Saunders, John, Liu, Xin-Jun, Chen, Ta-Kung, Bozigian, Haig, Grigoriadis, Dimitri E.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 193 KB

english, 2004

17

6,7-Dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-Like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain

Yun-Fei Zhu, Keith Wilcoxen, Timothy Gross, Patrick Connors, Nathalie Strack, Raymond Gross, Charles Q. Huang, James R. McCarthy, Qiu Xie, Nicholas Ling, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 188 KB

english, 2003

18

Biomimetic Catalysis of Intermodular Aminoacyl Transfer

Wilcoxen, Keith M., Leman, Luke J., Weinberger, Dana A., Huang, Zheng-Zheng, Ghadiri, M. Reza

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 139 KB

english, 2007

19

Synthesis of fluorinated olefins via the palladium catalyzed cross-coupling reaction of 1-fluorovinyl halides with organoboranes

Chen Chen, Keith Wilcoxen, Nathalie Strack, James R. McCarthy

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 186 KB

english, 1999

20

Quinoline-Carboxylic acids are potent inhibitors that inhibit the binding of insulin-Like growth factor (IGF) to IGF-Binding proteins

Yun-Fei Zhu, Xiao-Chuan Wang, Patrick Connors, Keith Wilcoxen, Yinghong Gao, Raymond Gross, Nathalie Strack, Timothy Gross, James R. McCarthy, Qiu Xie, Nicholas Ling, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 236 KB

english, 2003

21

ChemInform Abstract: An Improved Synthesis of Selectively Protected L-Dopa Derivatives from L-Tyrosine.

Chen Chen, Yun-Fei Zhu, Keith Wilcoxen

Journal:

Year:

2000

File:

PDF, 28 KB

2000

22

Synthesis of 3-Phenylpyrazolo[4,3-b]pyridines via a Convenient Synthesis of 4-Amino-3-arylpyrazoles and SAR of Corticotropin-Releasing Factor Receptor Type-1 Antagonists.

Keith Wilcoxen, Charles Q. Huang, James R. McCarthy, Dimitri E. Grigoriadis, Chen Chen

Journal:

Year:

2003

File:

PDF, 139 KB

2003

23

Synthesis of 1-Methyl-3-phenylpyrazolo[4,3-b]pyridines via a Methylation of 4-Phthalimino-3-phenylpyrazoles and Optimization Toward Highly Potent Corticotropin-Releasing Factor Type-1 Antagonists.

Charles Q. Huang, Keith Wilcoxen, James R. McCarthy, Mustaph Haddach, Dimitri Grigoriadis, Chen Chen

Journal:

Year:

2003

File:

PDF, 98 KB

2003

24

N-aroyloxy-2-thiopyridones as efficient oxygen-radical generators: novel time-controlled DNA photocleaving reagents

Theodorakis, Emmanuel A., Wilcoxen, Keith M.

Journal:

Chemical Communications

Year:

1996

Language:

english

File:

PDF, 425 KB

english, 1996

25

Intersectional innovation in biomarker development for patient-centric medicine

Wilcoxen, Keith M, Hesterman, Jacob, Orcutt, Kelly Davis, Hoppin, Jack

Journal:

Personalized Medicine

Year:

2011

Language:

english

File:

PDF, 2.93 MB

english, 2011

26

Optimization of 3-Phenylpyrazolo[1,5-a]pyrimidines as Potent Corticotropin-Releasing Factor-1 Antagonists with Adequate Lipophilicity and Water Solubility.

Chen Chen, Keith M. Wilcoxen, Charles Q. Huang, James R. McCarthy, Takung Chen, Dimitri E. Grigoriadis

Journal:

Year:

2004

Language:

english

File:

PDF, 19 KB

english, 2004

27

Development of non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonists

Dimitri E. Grigoriadis, Chen Chen, Marge Lorang, Keith Wilcoxen, Xin-Jun Liu, Nick Ling

Journal:

Psychoneuroendocrinology

Year:

2000

Language:

english

File:

PDF, 95 KB

english, 2000

28

Spectroscopic Characterization of an Eight‐Iron Nitrogenase Cofactor Precursor that Lacks the “9 th Sulfur”

Jasniewski, Andrew J., Wilcoxen, Jarett, Tanifuji, Kazuki, Hedman, Britt, Hodgson, Keith O., Britt, R. David, Hu, Yilin, Ribbe, Markus W.

Journal:

Angewandte Chemie

Year:

2019

File:

PDF, 1.86 MB

2019

29

ChemInform Abstract: Coupling of 2-Substituted 1-Fluorovinylstannanes with Organic Halides Catalyzed by Palladium(0)/Copper(I) Iodide. A Mild and Stereospecific Method to Monofluoroolefins.

Chen Chen, Keith Wilcoxen, Yun-Fei Zhu, Kyung-il Kim, James R. McCarthy

Journal:

Year:

1999

File:

PDF, 36 KB

1999

30

Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-Releasing factor receptor type-1 antagonists

Keith Wilcoxen, Charles Q Huang, James R McCarthy, Dimitri E Grigoriadis, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 180 KB

english, 2003

31

ChemInform Abstract: New Methods for the Synthesis of Fluoroolefins via the Palladium Catalyzed Cross-Coupling Reaction of 1-Fluorovinyl Halides with Organoboranes and Organostannanes.

Chen Chen, Keith Wilcoxen, Charles Q. Huang, Nathalie Strack, James R. McCarthy

Journal:

Year:

2000

File:

PDF, 30 KB

2000

32

Design, synthesis and structure–Activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

Timothy D. Gross, Yun-Fei Zhu, John Saunders, Keith M. Wilcoxen, Yinghong Gao, Patrick J. Connors Jr., Zhiqiang Guo, R.Scott Struthers, Greg J. Reinhart, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 105 KB

english, 2002

33

Synthesis of 1-methyl-3-phenylpyrazolo[4,3-b]pyridines via a methylation of 4-phthalimino-3-phenylpyrazoles and optimization toward highly potent corticotropin-releasing factor type-1 antagonists

Charles Q. Huang, Keith Wilcoxen, James R. McCarthy, Mustaph Haddach, Dimitri Grigoriadis, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 153 KB

english, 2003

34

Automated Mass Spectrometric Sequence Determination of Cyclic Peptide Library Members

Redman, James E., Wilcoxen, Keith M., Ghadiri, M. Reza

Journal:

Journal of Combinatorial Chemistry

Year:

2003

Language:

english

File:

PDF, 105 KB

english, 2003

35

Synthesis of New Four-Atom-Linked Capped Porphyrins

Ma, Wuping, Wilcoxen, Keith W., Szewczyk, Jason W., Ibers, James A.

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 402 KB

english, 1995

36

Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination

Jones, Philip, Wilcoxen, Keith, Rowley, Michael, Toniatti, Carlo

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.41 MB

english, 2015

37

ChemInform Abstract: Synthesis of Fluorinated Olefins via the Palladium Catalyzed Cross-Coupling Reaction of 1-Fluorovinyl Halides with Organoboranes.

Chen Chen, Keith Wilcoxen, Nathalie Strack, James R. McCarthy

Journal:

Year:

1999

File:

PDF, 30 KB

1999

38

Spectroscopic Characterization of an Eight-Iron Nitrogenase Cofactor Precursor That Lacks the “9th Sulfur”

Jasniewski, Andrew J, Wilcoxen, Jarett, Tanifuji, Kazuki, Hedman, Britt, Hodgson, Keith O, Britt, R David, Hu, Yilin, Ribbe, Markus Walter

Journal:

Angewandte Chemie International Edition

Year:

2019

Language:

english

File:

PDF, 1.85 MB

english, 2019

39

Spectroscopic Characterization of an Eight‐Iron Nitrogenase Cofactor Precursor that Lacks the “9 th Sulfur”

Jasniewski, Andrew J., Wilcoxen, Jarett, Tanifuji, Kazuki, Hedman, Britt, Hodgson, Keith O., Britt, R. David, Hu, Yilin, Ribbe, Markus W.

Journal:

Angewandte Chemie

Year:

2019

Language:

english

File:

PDF, 1.86 MB

english, 2019

40

ChemInform Abstract: Synthesis and Initial Structure—Activity Relationships of a Novel Series of Imidazolo[1,2-a]pyrimid-5-ones as Potent GnRH Receptor Antagonists

Keith M. Wilcoxen, Yun-Fei Zhu, Patrick J. Connors Jr., John Saunders, Timothy D. Gross, Yinghong Gao, Greg J. Reinhart, R. Scott Struthers, Chen Chen

Journal:

Year:

2002

File:

PDF, 34 KB

2002

41

Initial Structure–Activity Relationship Studies of a Novel Series of Pyrrolo[1,2-a]pyrimid-7-ones as GnRH Receptor Antagonists

Yun-Fei Zhu, R.Scott Struthers, Patrick J. Connors, Jr., Yinghong Gao, Timothy D. Gross, John Saunders, Keith Wilcoxen, Greg J. Reinhart, Nicholas Ling, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 121 KB

english, 2002

42

Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition

Srinivasan, Gayathri, Sidhu, Gurjit Singh, Williamson, Elizabeth A., Jaiswal, Aruna S., Najmunnisa, Nasreen, Wilcoxen, Keith, Jones, Dennie, George, Thomas J., Hromas, Robert

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2017

Language:

english

File:

PDF, 618 KB

english, 2017

43

ChemInform Abstract: Design, Synthesis and Structure—Activity Relationships of Novel Imidazolo[1,2-a]pyrimid-5-ones as Potent GnRH Receptor Antagonists.

Timothy D. Gross, Yun-Fei Zhu, John Saunders, Keith M. Wilcoxen, Yinghong Gao, Patrick J. Connors Jr., Zhiqiang Guo, R. Scott Struthers, Greg J. Reinhart, Chen Chen

Journal:

Year:

2002

File:

PDF, 29 KB

2002

44

A Novel Synthesis of 2-Arylpyrrolo[1,2-a]pyrimid-7-ones and Their Structure–Activity Relationships as Potent GnRH Receptor Antagonists

Yun-Fei Zhu, Keith Wilcoxen, John Saunders, Zhiqiang Guo, Yinghong Gao, Patrick J. Connors, Jr., Timothy D. Gross, Fabio C. Tucci, R. Scott Struthers, Greg J. Reinhart, Qiu Xie, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002

45

Functional and Mechanistic Analyses of Biomimetic Aminoacyl Transfer Reactions in de Novo Designed Coiled Coil Peptides via Rational Active Site Engineering

Leman, Luke J., Weinberger, Dana A., Huang, Zheng-Zheng, Wilcoxen, Keith M., Ghadiri, M. Reza

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 254 KB

english, 2007

46

An Improved Synthesis of Selectively Protected l -Dopa Derivatives from l -Tyrosine

Chen,, Zhu, Yun-Fei, Wilcoxen, Keith

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 138 KB

english, 2000

47

Coupling of 2-Substituted 1-Fluorovinylstannanes with Organic Halides Catalyzed by Palladium(0)/Copper(I) Iodide. A Mild and Stereospecific Method to Monofluoroolefins

Chen,, Wilcoxen, Keith, Zhu, Yun-Fei, Kim, Kyung-il, McCarthy, James R.

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 98 KB

english, 1999

48

Antiviral cyclic d,l-α-peptides: Targeting a general biochemical pathway in virus infections

W. Seth Horne, Christopher M. Wiethoff, Chunli Cui, Keith M. Wilcoxen, Manuel Amorin, M. Reza Ghadiri, Glen R. Nemerow

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 332 KB

english, 2005

49

A convenient one-pot synthesis of 4-amino-3-arylpyrazoles from α-phthaloylaminoacetophenones

Chen Chen, Keith Wilcoxen, James R. McCarthy

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 212 KB

english, 1998

50

Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility

Chen Chen, Keith M Wilcoxen, Charles Q Huang, James R McCarthy, Takung Chen, Dimitri E Grigoriadis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 276 KB

english, 2004

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